Drug General Information
Drug ID	D03PLP
Former ID	DNC006555
Drug Name	[1,1':2',1'']-terphenyl-4,3'',5''-triol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528198]
Structure		Download 2D MOL 3D MOL
Formula	C18H14O3
PubChem Compound ID	11579996
Target and Pathway
Target(s)	Proto-oncogene c-Abl	Target Info	Inhibitor	[528198]
	Multidrug resistance protein 1	Target Info	Inhibitor	[528198]
KEGG Pathway	ErbB signaling pathway
	Ras signaling pathway
	Cell cycle
	Axon guidance
	Neurotrophin signaling pathway
	Pathogenic Escherichia coli infection
	Shigellosis
	Pathways in cancer
	MicroRNAs in cancer
	Chronic myeloid leukemia
	Viral myocarditishsa02010:ABC transporters
	Bile secretion
NetPath Pathway	IL2 Signaling Pathway
	TCR Signaling Pathway
PANTHER Pathway	Axon guidance mediated by Slit/Robo
Pathway Interaction Database	p73 transcription factor network
	ATM pathway
	Regulation of Telomerase
	Posttranslational regulation of adherens junction stability and dissassembly
	Lissencephaly gene (LIS1) in neuronal migration and development
	PDGFR-beta signaling pathway
	Neurotrophic factor-mediated Trk receptor signaling
	Validated transcriptional targets of TAp63 isoforms
	p53 pathway
	Regulation of retinoblastoma proteinhif1_tfpathway:HIF-1-alpha transcription factor network
Reactome	Regulation of actin dynamics for phagocytic cup formation
	CDO in myogenesis
	RHO GTPases Activate WASPs and WAVEs
	HDR through Single Strand Annealing (SSA)
	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
	Factors involved in megakaryocyte development and platelet productionR-HSA-382556:ABC-family proteins mediated transport
WikiPathways	Apoptosis-related network due to altered Notch3 in ovarian cancer
	Fcgamma receptor (FCGR) dependent phagocytosis
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Integrated Pancreatic Cancer Pathway
	Pathogenic Escherichia coli infection
	Regulation of Microtubule Cytoskeleton
	Integrated Breast Cancer Pathway
	Signaling by Robo receptor
	Myogenesis
	Factors involved in megakaryocyte development and platelet productionWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
	Abacavir transport and metabolism
	Multi Drug Resistance Protein 1 (Glycoprotein 1) Regulation
	Allograft Rejection
	Drug Induction of Bile Acid Pathway
	Codeine and Morphine Metabolism
References
Ref 528198	J Med Chem. 2006 May 18;49(10):3012-8.Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.
Ref 528198	J Med Chem. 2006 May 18;49(10):3012-8.Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.

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