Drug General Information
Drug ID
D03PLH
Former ID
DIB021101
Drug Name
U46619
Synonyms
U 46619; U46619; 11alpha,9alpha-epoxymethano-PGH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539187]
Structure
Download
2D MOL
Formula
C21H34O4
InChI
InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1
InChIKey
LQANGKSBLPMBTJ-BRSNVKEHSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Agonist [534595]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [525673]
Prostacyclin receptor Target Info Agonist [525673]
Prostaglandin E2 receptor, EP1 subtype Target Info Agonist [534595]
Putative G-protein coupled receptor 44 Target Info Agonist [526477]
Prostaglandin F2-alpha receptor Target Info Agonist [525673]
Prostaglandin D2 receptor Target Info Agonist [525673]
Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [534595]
Thromboxane A2 receptor Target Info Agonist [525673]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04020:Calcium signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activationhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Platelet activation
NetPath Pathway IL2 Signaling PathwayNetPath_25:FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway PI3 kinase pathway
Pathway Interaction Database Thromboxane A2 receptor signalingtxa2pathway:Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and ProstacyclinPW000451:Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Endothelin Pathways
Platelet homeostasis
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
GPCRs, OtherWP98:Prostaglandin Synthesis and Regulation
Vitamin D Receptor Pathway
Signal amplification
References
Ref 539187(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1888).
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.
Ref 526477Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72.
Ref 534595Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41.

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