Drug General Information
Drug ID	D03OFN
Former ID	DIB011444
Drug Name	NK-314
Synonyms	Topoisomerase modulator, Nippon Kayaku
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[547889]
Company	Nippon Kayaku Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	[n+]12c3c(c4c(c1CCC2)c(c(cc4)OC)O)ccc1c3cc2c(c1)OCO2.[C<br />l-]
Target and Pathway
Target(s)	DNA topoisomerase II	Target Info	Modulator	[536762]
References
Ref 547889	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020174)
Ref 536762	NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem. 2008 Aug 29;283(35):23711-20. Epub 2008 Jul 2.

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