Drug Information

Drug General Information
Drug ID
D03NZU
Former ID
DIB019865
Drug Name
FMOC-L-Leucine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539765]
Structure
Download
2D MOL
Formula
C21H23NO4
InChI
InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)
InChIKey
CBPJQFCAFFNICX-UHFFFAOYSA-N
PubChem Compound ID
4308
PubChem Substance ID
459985, 3147869, 7406351, 8152678, 14803032, 25169402, 26749936, 26758709, 29223407, 49832584, 53800774, 78953479, 81040833, 85086177, 85788106, 91045430, 92715529, 103224486, 103837426, 103942936, 104306026, 105591405, 117543988, 118306596, 125333871, 125338480, 125348812, 130920425, 135055689, 135650280, 142230319, 143120349, 143431443, 144238752, 162022589, 162284269, 162291672, 163140970, 163688134, 164810453, 167785837, 179148705, 184549900, 184550100, 184616284, 206245520, 206245560, 208264984, 212305960, 223396607
Target and Pathway
Target(s) mRNA of PPAR-gamma Target Info Agonist [526183]
KEGG Pathway PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma protein
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
Adipogenesis
SREBP signalling
Nuclear Receptors
References
Ref 539765(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2705).
Ref 526183A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell. 2001 Oct;8(4):737-47.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.