Drug Information

Drug General Information
Drug ID
D03MNO
Former ID
DNC000849
Drug Name
L-658,758
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538111]
Structure
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2D MOL

3D MOL
Formula
C16H20N2O9S
Canonical SMILES
CC(=O)OCC1=C(N2C(C(C2=O)OC)S(=O)(=O)C1)C(=O)N3CCCC3C(=O<br />)O
InChI
1S/C16H20N2O9S/c1-8(19)27-6-9-7-28(24,25)15-12(26-2)14(21)18(15)11(9)13(20)17-5-3-4-10(17)16(22)23/h10,12,15H,3-7H2,1-2H3,(H,22,23)/t10-,12-,15+/m0/s1
InChIKey
SMZXYXKZTNLAKY-ITDIGPHOSA-N
CAS Number
CAS 21735-70-6
PubChem Compound ID
121963
PubChem Substance ID
10239889, 14855687, 29302450, 50070469, 50071110, 57339876, 77435468, 103273796, 104127880, 104414712, 134339071, 134340160, 134341324, 135077949, 160847509
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [538111]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 538111Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol. 1998 Aug;275(2 Pt 2):H385-92.
Ref 538111Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol. 1998 Aug;275(2 Pt 2):H385-92.

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