Drug General Information
Drug ID	D03LCM
Former ID	DNC006721
Drug Name	3-chloro-N-(6-chloropyridin-2-yl)benzamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528186]
Structure		Download 2D MOL 3D MOL
Formula	C12H8Cl2N2O
Canonical SMILES	C1=CC(=CC(=C1)Cl)C(=O)NC2=NC(=CC=C2)Cl
InChI	1S/C12H8Cl2N2O/c13-9-4-1-3-8(7-9)12(17)16-11-6-2-5-10(14)15-11/h1-7H,(H,15,16,17)
InChIKey	FCJWDXAXERKUEZ-UHFFFAOYSA-N
PubChem Compound ID	44412923
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[528186]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 528186	Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. Epub 2006 May 5.Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.
Ref 528186	Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. Epub 2006 May 5.Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.

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