Drug General Information |
Drug ID |
D03JTG
|
Former ID |
DIB010509
|
Drug Name |
Fruquintinib
|
Synonyms |
HMPL-013
|
Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Phase 3 |
[1]
|
Company |
Hutchison Medipharma Enterprises Ltd
|
Structure |
|
Download
2D MOL
3D MOL
|
Target and Pathway |
Target(s) |
Vascular endothelial growth factor receptor 1 |
Target Info |
Inhibitor |
[2]
|
Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[2]
|
Vascular endothelial growth factor receptor 3 |
Target Info |
Inhibitor |
[2]
|
KEGG Pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
Cytokine-cytokine receptor interaction
|
HIF-1 signaling pathway
|
Endocytosis
|
PI3K-Akt signaling pathway
|
Focal adhesion
|
Transcriptional misregulation in cancer
|
Rheumatoid arthritishsa04014:Ras signaling pathway
|
VEGF signaling pathway
|
Proteoglycans in cancerhsa04014:Ras signaling pathway
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
|
PANTHER Pathway
|
Angiogenesis
|
VEGF signaling pathway
|
Pathway Interaction Database
|
Glypican 1 network
|
HIF-2-alpha transcription factor network
|
S1P3 pathway
|
VEGF and VEGFR signaling network
|
VEGFR1 specific signals
|
Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
|
Beta3 integrin cell surface interactions
|
Signaling events mediated by TCPTP
|
SHP2 signaling
|
S1P1 pathway
|
Integrins in angiogenesis
|
Signaling events mediated by VEGFR1 and VEGFR2
|
Notch-mediated HES/HEY networkvegf_vegfr_pathway:VEGF and VEGFR signaling network
|
VEGFR3 signaling in lymphatic endothelium
|
Reactome
|
Neurophilin interactions with VEGF and VEGFR
|
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
VEGF binds to VEGFR leading to receptor dimerization
|
Integrin cell surface interactions
|
EPHA-mediated growth cone collapse
|
VEGFA-VEGFR2 Pathway
|
VEGFR2 mediated cell proliferationR-HSA-195399:VEGF binds to VEGFR leading to receptor dimerization
|
WikiPathways
|
Focal Adhesion
|
Signaling by VEGF
|
AngiogenesisWP306:Focal Adhesion
|
Nifedipine Activity
|
Cardiac Progenitor Differentiation
|
AngiogenesisWP1919:Signaling by VEGF
|
References |
REF 1 | ClinicalTrials.gov (NCT02314819) A Phase III Trial Evaluating Fruquintinib Efficacy and Safety in 3+ Line Colorectal Cancer Patients ???RESCO). U.S. National Institutes of Health. |
---|
REF 2 | Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy. Cancer Biol Ther. 2014;15(12):1635-45. |