Drug Information

Drug General Information
Drug ID
D03JRX
Former ID
DNC011236
Drug Name
N-n-dodecyl-7-methoxytacrine hydrochloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531150]
Structure
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2D MOL

3D MOL
Formula
C26H41ClN2O
Canonical SMILES
CCCCCCCCCCCCNC1=C2CCCCC2=NC3=C1C=C(C=C3)OC.Cl
InChI
1S/C26H40N2O.ClH/c1-3-4-5-6-7-8-9-10-11-14-19-27-26-22-15-12-13-16-24(22)28-25-18-17-21(29-2)20-23(25)26;/h17-18,20H,3-16,19H2,1-2H3,(H,27,28);1H
InChIKey
OGPLWBUXUWFPIK-UHFFFAOYSA-N
PubChem Compound ID
52945009
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [531150]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 531150Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. Epub 2010 Aug 16.Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.
Ref 531150Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. Epub 2010 Aug 16.Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.

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