TTD | Drug: D03JRJ

Drug General Information
Drug ID	D03JRJ
Former ID	DIB011983
Drug Name	NTE-122
Synonyms	ACAT inhibitor, Nissin Food
Indication	Atherosclerosis [ICD9: 414.0, 440; ICD10:I70]		Terminated	[546451]
Company	Nissin Foods Holdings Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(N(C[C@H]1CC[C@H](CN(C(=O)Nc2ccc(N(C)C)cc2)C2CCCCC<br />2)CC1)C1CCCCC1)Nc1ccc(N(C)C)cc1
CAS Number	CAS 166967-85-7
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[534779]
KEGG Pathway	Drug metabolism - other enzymes
KEGG Pathway	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 546451	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008195)
Ref 534779	Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits. Jpn J Pharmacol. 1998 Nov;78(3):355-64.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information