Drug Information

Drug General Information
Drug ID
D03IVG
Former ID
DIB020045
Drug Name
imiloxan
Synonyms
RS-21361; GNF-Pf-2156
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540409]
Structure
Download
2D MOL
Formula
C14H16N2O2
InChI
InChI=1S/C14H16N2O2/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11/h3-8,11H,2,9-10H2,1H3
InChIKey
UXABARREKCJULM-UHFFFAOYSA-N
PubChem Compound ID
133621
PubChem Substance ID
7734666, 7979597, 10243413, 12012640, 15019917, 26752007, 29311505, 47500596, 47647598, 48244473, 50104679, 57344592, 79391242, 85209112, 85788122, 90341379, 103073023, 103084716, 103411089, 104171179, 104380223, 117603563, 124749929, 124880475, 124880476, 126437710, 129432694, 131332122, 135089115, 136351334, 136368380, 137006275, 143259520, 144203726, 170466588, 178100464, 179293618, 184591510, 223682208, 224859049, 227042536, 249980832
Target and Pathway
Target(s) Alpha-2B adrenergic receptor Target Info Antagonist [530335]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
GPCR ligand binding
GPCR downstream signaling
References
Ref 540409(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3470).
Ref 530335Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Br J Pharmacol. 1990 Mar;99(3):560-4.

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