Drug Information

Drug General Information
Drug ID
D03FQU
Former ID
DNC014226
Drug Name
H-Tyr-Pro-Phe-Ala-NH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530745]
Structure
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2D MOL

3D MOL
Formula
C26H33N5O5
Canonical SMILES
CC(C(=O)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2CCCN2C(=O)C(CC3=<br />CC=C(C=C3)O)N
InChI
1S/C26H33N5O5/c1-16(23(28)33)29-24(34)21(15-17-6-3-2-4-7-17)30-25(35)22-8-5-13-31(22)26(36)20(27)14-18-9-11-19(32)12-10-18/h2-4,6-7,9-12,16,20-22,32H,5,8,13-15,27H2,1H3,(H2,28,33)(H,29,34)(H,30,35)/t16-,20-,21-,22-/m0/s1
InChIKey
WNYNLZIGNIJEJM-KPQYALRZSA-N
PubChem Compound ID
44428877
Target and Pathway
Target(s) Substance-P receptor Target Info Inhibitor [530745]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 530745J Med Chem. 2010 Mar 25;53(6):2383-9.Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.
Ref 530745J Med Chem. 2010 Mar 25;53(6):2383-9.Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.

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