Drug Information
Drug General Information | |||||
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Drug ID |
D03CMR
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Former ID |
DIB000600
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Drug Name |
TER-16998
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Synonyms |
TER-16998; TER-17411; TER-17529; TLK-16998; TLK-17411; TLK-19780; TLK-19781; Insulin receptor activators (oral, diabetes mellitus); Insulin receptor activators (oral, diabetes mellitus), ReceptorBio; Insulin receptor activators (oral, diabetes), Telik/Sanwa
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Indication | Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] | Terminated | [1] | ||
Company |
Telik Inc
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Structure |
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Download2D MOL |
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Canonical SMILES |
S(=O)(=O)(c1cc(c2c(c1)cc(NC(=O)Nc1cc3c(c(cc(S(=O)(=O)Nc<br />4cc(S(=O)(=O)O)c(cc4)Cl)c3)O)cc1)cc2)O)Nc1cc(S(=O)(=O)O<br />)c(cc1)Cl
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CAS Number |
CAS 210978-64-6
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Target and Pathway | |||||
Target(s) | Insulin receptor | Target Info | Activator | [2] | |
KEGG Pathway | Ras signaling pathway | ||||
Rap1 signaling pathway | |||||
cGMP-PKG signaling pathway | |||||
HIF-1 signaling pathway | |||||
FoxO signaling pathway | |||||
PI3K-Akt signaling pathway | |||||
AMPK signaling pathway | |||||
Adherens junction | |||||
Insulin signaling pathway | |||||
Ovarian steroidogenesis | |||||
Type II diabetes mellitus | |||||
Non-alcoholic fatty liver disease (NAFLD) | |||||
Aldosterone-regulated sodium reabsorption | |||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
PANTHER Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | ||||
Insulin/IGF pathway-protein kinase B signaling cascade | |||||
PI3 kinase pathway | |||||
Pathway Interaction Database | Insulin Pathway | ||||
Signaling events mediated by PTP1B | |||||
Signaling events mediated by TCPTP | |||||
Insulin-mediated glucose transport | |||||
PathWhiz Pathway | Insulin Signalling | ||||
Leucine Stimulation on Insulin Signaling | |||||
Reactome | IRS activation | ||||
Signal attenuation | |||||
Insulin receptor signalling cascade | |||||
Insulin receptor recycling | |||||
WikiPathways | DNA Damage Response (only ATM dependent) | ||||
Insulin Signaling | |||||
Nanoparticle triggered autophagic cell death | |||||
AGE/RAGE pathway | |||||
Signaling by Insulin receptor | |||||
Folate Metabolism | |||||
Type II diabetes mellitus | |||||
Vitamin B12 Metabolism | |||||
Selenium Micronutrient Network | |||||
AMPK Signaling | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007187) | ||||
REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). | ||||
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