Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03CMR
|
||||
| Former ID |
DIB000600
|
||||
| Drug Name |
TER-16998
|
||||
| Synonyms |
TER-16998; TER-17411; TER-17529; TLK-16998; TLK-17411; TLK-19780; TLK-19781; Insulin receptor activators (oral, diabetes mellitus); Insulin receptor activators (oral, diabetes mellitus), ReceptorBio; Insulin receptor activators (oral, diabetes), Telik/Sanwa
|
||||
| Indication | Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] | Terminated | [1] | ||
| Company |
Telik Inc
|
||||
| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
S(=O)(=O)(c1cc(c2c(c1)cc(NC(=O)Nc1cc3c(c(cc(S(=O)(=O)Nc<br />4cc(S(=O)(=O)O)c(cc4)Cl)c3)O)cc1)cc2)O)Nc1cc(S(=O)(=O)O<br />)c(cc1)Cl
|
||||
| CAS Number |
CAS 210978-64-6
|
||||
| Target and Pathway | |||||
| Target(s) | Insulin receptor | Target Info | Activator | [2] | |
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| cGMP-PKG signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| FoxO signaling pathway | |||||
| PI3K-Akt signaling pathway | |||||
| AMPK signaling pathway | |||||
| Adherens junction | |||||
| Insulin signaling pathway | |||||
| Ovarian steroidogenesis | |||||
| Type II diabetes mellitus | |||||
| Non-alcoholic fatty liver disease (NAFLD) | |||||
| Aldosterone-regulated sodium reabsorption | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| PANTHER Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | ||||
| Insulin/IGF pathway-protein kinase B signaling cascade | |||||
| PI3 kinase pathway | |||||
| Pathway Interaction Database | Insulin Pathway | ||||
| Signaling events mediated by PTP1B | |||||
| Signaling events mediated by TCPTP | |||||
| Insulin-mediated glucose transport | |||||
| PathWhiz Pathway | Insulin Signalling | ||||
| Leucine Stimulation on Insulin Signaling | |||||
| Reactome | IRS activation | ||||
| Signal attenuation | |||||
| Insulin receptor signalling cascade | |||||
| Insulin receptor recycling | |||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| Insulin Signaling | |||||
| Nanoparticle triggered autophagic cell death | |||||
| AGE/RAGE pathway | |||||
| Signaling by Insulin receptor | |||||
| Folate Metabolism | |||||
| Type II diabetes mellitus | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007187) | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.