Drug General Information
Drug ID	D03BUG
Former ID	DNC013921
Drug Name	1-(benzofuran-2-yl)-3-aza-bicyclo[3.1.0]hexane
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529523]
Structure		Download 2D MOL 3D MOL
Formula	C13H13NO
Canonical SMILES	C1C2C1(CNC2)C3=CC4=CC=CC=C4O3
InChI	1S/C13H13NO/c1-2-4-11-9(3-1)5-12(15-11)13-6-10(13)7-14-8-13/h1-5,10,14H,6-8H2
InChIKey	FRXUZFQLSGFGPV-UHFFFAOYSA-N
PubChem Compound ID	44561205
Target and Pathway
Target(s)	Sodium-dependent serotonin transporter	Target Info	Inhibitor	[529523]
	Sodium-dependent dopamine transporter	Target Info	Inhibitor	[529523]
KEGG Pathway	Serotonergic synapsehsa04728:Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
	5HT2 type receptor mediated signaling pathway
	5HT3 type receptor mediated signaling pathway
	5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
	Parkinson disease
	Dopamine receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
Reactome	Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	SIDS Susceptibility Pathways
	NRF2 pathway
	Synaptic Vesicle Pathway
	Serotonin Transporter ActivityWP727:Monoamine Transport
	Dopaminergic Neurogenesis
	Parkinsons Disease Pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 529523	Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. Epub 2008 May 23.Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.
Ref 529523	Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. Epub 2008 May 23.Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.

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