Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03BMT
|
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| Former ID |
DIB015799
|
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| Drug Name |
EphB4 inhibitors
|
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| Synonyms |
EphB4 inhibitors (cancer); EphB4 inhibitors (cancer), AstraZeneca
|
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [1] | ||
| Company |
AstraZeneca plc
|
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1cnc(nc1Nc1c(ccc2c1OCO2)Cl)Nc1cc(cc(c1)N1CCOCC1)N1CCOC<br />C1
|
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| Target and Pathway | |||||
| Target(s) | Ephrin type-B receptor 4 | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Axon guidance | ||||
| Pathway Interaction Database | EPHB forward signaling | ||||
| EphrinB-EPHB pathway | |||||
| Ephrin B reverse signaling | |||||
| Reactome | EPH-Ephrin signaling | ||||
| EPHB-mediated forward signaling | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| WikiPathways | Vitamin D Receptor Pathway | ||||
| References | |||||
| REF 1 | Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6242-5 | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1833). | ||||
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