Drug General Information
Drug ID	D02VIV
Former ID	DNC013854
Drug Name	2-Hydrazino-3-methyl-4(3H)-quinazolinone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529873]
Structure		Download 2D MOL 3D MOL
Formula	C9H10N4O
Canonical SMILES	CN1C(=O)C2=CC=CC=C2N=C1NN
InChI	1S/C9H10N4O/c1-13-8(14)6-4-2-3-5-7(6)11-9(13)12-10/h2-5H,10H2,1H3,(H,11,12)
InChIKey	BQDOAXFBKRUNTF-UHFFFAOYSA-N
PubChem Compound ID	376484
Target and Pathway
Target(s)	Amine oxidase [flavin-containing] B	Target Info	Inhibitor	[529873]
BioCyc Pathway	Superpathway of tryptophan utilization
	Tryptophan degradation via tryptamine
	Dopamine degradation
	Putrescine degradation III
	Noradrenaline and adrenaline degradation
KEGG Pathway	Glycine, serine and threonine metabolism
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	Tryptophan metabolism
	Drug metabolism - cytochrome P450
	Metabolic pathways
	Serotonergic synapse
	Dopaminergic synapse
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	5-Hydroxytryptamine degredation
	Dopamine receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
WikiPathways	Tryptophan metabolism
	Dopamine metabolism
	Phase 1 - Functionalization of compounds
References
Ref 529873	Bioorg Med Chem. 2009 Jan 15;17(2):675-89. Epub 2008 Dec 3.New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 529873	Bioorg Med Chem. 2009 Jan 15;17(2):675-89. Epub 2008 Dec 3.New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.

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