Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02RWC
|
||||
| Former ID |
DIB019925
|
||||
| Drug Name |
GNF-5837
|
||||
| Synonyms |
GNF 5837; GNF5837
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C28H21F4N5O2
|
||||
| InChI |
InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
|
||||
| InChIKey |
YYDUWLSETXNJJT-MTJSOVHGSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | BDNF/NT-3 growth factors receptor | Target Info | Inhibitor | [1] | |
| Trk receptor | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | MAPK signaling pathway | ||||
| Neurotrophin signaling pathway | |||||
| Alcoholism | |||||
| Pathway Interaction Database | SHP2 signaling | ||||
| Posttranslational regulation of adherens junction stability and dissassembly | |||||
| Neurotrophic factor-mediated Trk receptor signaling | |||||
| Reactome | NGF-independant TRKA activationR-HSA-170984:ARMS-mediated activation | ||||
| NGF-independant TRKA activation | |||||
| PI3K/AKT activation | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| BDNF signaling pathwayWP382:MAPK Signaling Pathway | |||||
| BDNF signaling pathway | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| NGF signalling via TRKA from the plasma membrane | |||||
| References | |||||
| REF 1 | Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett. 2012 Jan 1;3(2):140-5. | ||||
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