| Drug General Information |
| Drug ID |
D02RQP
|
| Former ID |
DIB018981
|
| Drug Name |
bisphenol A
|
| Synonyms |
BPA
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C15H16O2
|
| InChI |
InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3
|
| InChIKey |
IISBACLAFKSPIT-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
68531, 81140, 586242, 893061, 3135927, 4950518, 7978799, 8154266, 10536202, 11533254, 14709383, 15220620, 16962392, 17389142, 17390010, 22389361, 24848090, 24848951, 24850948, 24850949, 24850952, 24854386, 24867221, 24867222, 25622888, 26736246, 26752849, 29225577, 32017005, 47365493, 48413311, 48416888, 48421347, 48421869, 48422978, 48424894, 48424895, 48425781, 48426108, 49718108, 49855899, 50105488, 50436459, 53786774, 56310669, 56311407, 56311428, 56311468, 56312131, 56312424
|
| Target and Pathway |
| Target(s) |
mRNA of androgen receptor |
Target Info |
Antagonist |
[2]
|
|---|
| Estrogen receptor beta |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
Oocyte meiosis
|
|
Pathways in cancer
|
|
Prostate cancerhsa04915:Estrogen signaling pathway
|
|
Prolactin signaling pathway
|
|
NetPath Pathway
|
EGFR1 Signaling Pathway
|
|
AndrogenReceptor Signaling Pathway
|
|
FSH Signaling Pathway
|
|
Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
|
Coregulation of Androgen receptor activity
|
|
Regulation of Androgen receptor activity
|
|
Nongenotropic Androgen signaling
|
|
Regulation of nuclear beta catenin signaling and target gene transcription
|
|
FOXA1 transcription factor network
|
|
Notch-mediated HES/HEY networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
|
|
Validated nuclear estrogen receptor beta network
|
|
Validated nuclear estrogen receptor alpha network
|
|
Reactome
|
Nuclear Receptor transcription pathway
|
|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-383280:Nuclear Receptor transcription pathway
|
|
WikiPathways
|
SIDS Susceptibility Pathways
|
|
Integrated Pancreatic Cancer Pathway
|
|
Prostate Cancer
|
|
Integrated Breast Cancer Pathway
|
|
Nuclear Receptors
|
|
Androgen receptor signaling pathwayWP706:SIDS Susceptibility Pathways
|
|
Ovarian Infertility Genes
|
| References |
| REF 1 | Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor. Toxicol Sci. 2003 Sep;75(1):40-6. Epub 2003 Jun 12. |
|---|
| REF 2 | Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERalpha-selective antagonist. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4031-6. |
|---|
