Drug Information

Drug General Information
Drug ID
D02NUT
Former ID
DIB018027
Drug Name
KU-60019
Drug Type
Small molecular drug
Indication Non-small cell lung cancer [ICD10:C33-C34] Clinical trial [530432]
Structure
Download
2D MOL
Formula
C30H33N3O5S
InChI
InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
InChIKey
SCELLOWTHJGVIC-BGYRXZFFSA-N
PubChem Compound ID
15953870
PubChem Substance ID
22425440, 26559769, 33336771, 104253219, 124757344, 124939250, 124939251, 125164148, 136348256, 136367551, 139585005, 141119833, 152258381, 160647218, 162011850, 162037670, 162202608, 163907986, 172914014, 174007027, 174531520, 184816792, 223704675, 229676619, 241178078, 241376848, 242559685, 245933171, 249565721, 249820233, 252088587, 252109980, 252157848, 252450576
Target and Pathway
Target(s) ATM serine/threonine kinase Target Info Inhibitor [530432]
References
Ref 530432Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.
Ref 530432Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.

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