Drug General Information
Drug ID	D02NQK
Former ID	DNC010940
Drug Name	4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530766]
Structure		Download 2D MOL 3D MOL
Formula	C10H9N3O3S2
Canonical SMILES	C1=CC=[N+](C(=C1)SC2=C(C=NC=C2)S(=O)(=O)N)[O-]
InChI	1S/C10H9N3O3S2/c11-18(15,16)9-7-12-5-4-8(9)17-10-3-1-2-6-13(10)14/h1-7H,(H2,11,15,16)
InChIKey	DQAURQJZVIJAAO-UHFFFAOYSA-N
PubChem Compound ID	46703924
Target and Pathway
Target(s)	Carbonic anhydrase I	Target Info	Inhibitor	[530766]
	Carbonic anhydrase IX	Target Info	Inhibitor	[530766]
	Carbonic anhydrase II	Target Info	Inhibitor	[530766]
	Carbonic anhydrase XII	Target Info	Inhibitor	[530766]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretionhsa00910:Nitrogen metabolism
NetPath Pathway	IL4 Signaling Pathway
	EGFR1 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database	C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network
PathWhiz Pathway	Gastric Acid Production
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
	Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
References
Ref 530766	Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.
Ref 530766	Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.

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