Drug Information

Drug General Information
Drug ID
D02NGU
Former ID
DIB019992
Drug Name
H-8
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539489]
Structure
Download
2D MOL
Formula
C12H15N3O2S
InChI
InChI=1S/C12H15N3O2S/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12/h2-6,9,13,15H,7-8H2,1H3
InChIKey
PJWUXKNZVMEPPH-UHFFFAOYSA-N
PubChem Compound ID
3540
PubChem Substance ID
645245, 841195, 7404189, 7888465, 7979490, 8152241, 11111503, 15417315, 26713166, 26755703, 29222671, 46393648, 46515520, 46530868, 47662087, 47736271, 48110267, 48184807, 50065300, 50111160, 57321862, 78388204, 85787245, 90341431, 99444468, 103072844, 103083245, 103389922, 104303812, 117630382, 118696517, 124658735, 124880800, 124880801, 126407649, 128926731, 134223625, 135061936, 135650343, 137245022, 141537158, 142783307, 143858039, 144107756, 145470216, 160969054, 162920721, 164758652, 164810761, 179148592
Target and Pathway
Target(s) CNGA1 Target Info Blocker (channel blocker) [534483]
References
Ref 539489(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2348).
Ref 534483Direct blockade of both cloned rat rod photoreceptor cyclic nucleotide-gated non-selective cation (CNG) channel alpha-subunit and native CNG channels from Xenopus rod outer segments by H-8, a non-specific cyclic nucleotide-dependent protein kinase inhibitor. Neurosci Lett. 1997 Sep 12;233(1):37-40.

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