Drug Information

Drug General Information
Drug ID
D02LPF
Former ID
DAP000989
Drug Name
Altretamine
Synonyms
Altretamina; Altretaminum; HEXAMETHYLMELAMINE; HMM; HTM; HXM; Hemel; Hexalen; Hexastat; Hexinawas; Altretamine Bellon Brand; Altretamine Chiesi Brand; Altretamine Wassermann Brand; Bellon Brand of Altretamine; Chiesi Brand of Altretamine; MGI Pharma Brand of Altretamine; Rhone Poulenc Rorer Brand of Altretamine; Wassermann Brand of Altretamine; A 8723; ENT 50852; NC 195; Altretamina [INN-Spanish]; Altretaminum [INN-Latin]; Hexalen (TN); Hexalen, Altretamine; KB-913; Rhone-Poulenc Rorer Brand of Altretamine; Altretamine (USP/INN); Altretamine [USAN:INN:BAN]; No-s-triazine; N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-2,4,6-triamine; N~2~,N~2~,N~4~,N~4~,N~6~,N~6~-Hexamethyl-1,3,5-triazine-2,4,6-triamine; 2,4, 6-Tris(dimethylamino)-1,3,5-triazine; 2,4,6-Tris(dimethylami; 2,4,6-Tris(dimethylamino)-1,3,5-triazine; 2,4,6-Tris(dimethylamino-s-triazine; 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Approved [538535], [542119]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C9H18N6
InChI
InChI=1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3
InChIKey
UUVWYPNAQBNQJQ-UHFFFAOYSA-N
CAS Number
CAS 645-05-6
PubChem Compound ID
2123
PubChem Substance ID
78208, 220082, 855523, 866238, 3297014, 7403876, 7861598, 7978484, 8149887, 8151440, 10531617, 11110789, 11110790, 11222335, 11335947, 11361186, 11364202, 11366764, 11369326, 11372141, 11374527, 11377488, 11405266, 11462158, 11466974, 11468094, 11484490, 11486807, 11488723, 11490766, 11492878, 11495122, 12013384, 14748896, 17396998, 17404646, 24278242, 24874728, 26612383, 26679553, 26746901, 26746902, 26746903, 29221302, 46505760, 47365225, 47440291, 47589031, 47589032, 47736514
ChEBI ID
ChEBI:24564
SuperDrug ATC ID
L01XX03
SuperDrug CAS ID
cas=000645056
Target and Pathway
Target(s) DNA Target Info Breaker [536640]
References
Ref 538535FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019926.
Ref 542119(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7112).
Ref 536640Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26. Epub 2008 Feb 28.

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