Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02KLD
|
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| Former ID |
DIB006976
|
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| Drug Name |
BVT-74316
|
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| Synonyms |
BVT-5182; BVT-5182C; 5-HT6 antagonists (obesity), Biovitrum; 5-HT6 antagonists (obesity), Proximagen
|
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| Drug Type |
Small molecular drug
|
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| Indication | Obesity [ICD9: 278; ICD10:E66] | Phase 1 | [1] | ||
| Company |
Swedish Orphan Biovitrum AB
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| Structure |
|
Download2D MOL |
|||
| Formula |
C21H24N2O5S
|
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| Canonical SMILES |
c1(ccc(c(c1)NS(=O)(=O)c1cc2c(c(c1)OC1CCNCC1)occ2)OC)C
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 6 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023034) | ||||
| REF 2 | Pharmacological targeting of the serotonergic system for the treatment of obesity. J Physiol. 2009 January 1; 587(Pt 1): 49-60. | ||||
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