Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02KKU
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| Former ID |
DNC008943
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| Drug Name |
Oleanonic acid
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| Synonyms |
3-Oxoolean-12-en-28-oic Acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [529507] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C30H46O3
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| Canonical SMILES |
CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(=O)C5(C)C)C)C)C2C1)C<br />)C(=O)O)C
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| InChI |
1S/C30H46O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-22H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,27-,28+,29+,30-/m0/s1
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| InChIKey |
FMIMFCRXYXVFTA-FUAOEXFOSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | mRNA of Protein tyrosine phosphatase-1B | Target Info | Inhibitor | [529697] | |
| Glycogen phosphorylase, muscle form | Target Info | Inhibitor | [529507] | ||
| BioCyc Pathway | Glycogenolysis | ||||
| NetPath Pathway | FSH Signaling Pathway | ||||
| Pathway Interaction Database | Insulin Pathway | ||||
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | |||||
| Signaling events mediated by PTP1B | |||||
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | |||||
| Signaling events mediated by TCPTP | |||||
| IGF1 pathway | |||||
| EGF receptor (ErbB1) signaling pathway | |||||
| Posttranslational regulation of adherens junction stability and dissassembly | |||||
| PDGFR-beta signaling pathway | |||||
| N-cadherin signaling events | |||||
| References | |||||
| Ref 529507 | J Med Chem. 2008 Jun 26;51(12):3540-54. Epub 2008 Jun 3.Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. | ||||
| Ref 529697 | J Nat Prod. 2008 Oct;71(10):1775-8. Epub 2008 Sep 18.Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. | ||||
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