Drug General Information
Drug ID
D02JUT
Former ID
DNC000149
Drug Name
Acivicin
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 3 [544734]
Structure
Download
2D MOL

3D MOL

Formula
C5H7ClN2O3
Canonical SMILES
C1C(ON=C1Cl)C(C(=O)O)N
InChI
1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1
InChIKey
QAWIHIJWNYOLBE-OKKQSCSOSA-N
CAS Number
CAS 42228-92-2
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Carbamoyl-phosphate synthase II Target Info Inhibitor [537677]
CTP synthase Target Info Inhibitor [535177], [537820]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PANTHER Pathway De novo pyrimidine ribonucleotides biosythesis
PathWhiz Pathway Pyrimidine Metabolism
WikiPathways Metabolism of nucleotides
References
Ref 544734Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000775)
Ref 535177Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6412-6. Epub 2001 May 15.
Ref 537677Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis. Biochem Biophys Res Commun. 1990 Jul 31;170(2):426-32.
Ref 537820Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid. Cancer Res. 1981 Sep;41(9 Pt 1):3419-23.

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