Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02JNX
|
||||
| Former ID |
DIB003092
|
||||
| Drug Name |
OxycoDex
|
||||
| Synonyms |
Oxycodone/dextromethorphan
|
||||
| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Discontinued in Phase 2 | [1] | ||
| Company |
Endo Pharmaceuticals
|
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| Target and Pathway | |||||
| Target(s) | Opioid receptor | Target Info | Modulator | [2] | |
| Sodium-dependent serotonin transporter | Target Info | Inhibitor | [3], [4] | ||
| Sigma(1)-type opioid receptor | Target Info | Modulator | [3], [4] | ||
| KEGG Pathway | Serotonergic synapse | ||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | 5HT1 type receptor mediated signaling pathway | ||||
| 5HT2 type receptor mediated signaling pathway | |||||
| 5HT3 type receptor mediated signaling pathway | |||||
| 5HT4 type receptor mediated signaling pathway | |||||
| WikiPathways | Monoamine Transport | ||||
| SIDS Susceptibility Pathways | |||||
| NRF2 pathway | |||||
| Synaptic Vesicle Pathway | |||||
| Serotonin Transporter ActivityWP2006:miR-targeted genes in squamous cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017613) | ||||
| REF 2 | Differential activation of the ?-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model. Br J Pharmacol. 2013 Jan;168(2):375-88. | ||||
| REF 3 | Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. | ||||
| REF 4 | Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. | ||||
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