Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02JIS
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| Former ID |
DNAP001705
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| Drug Name |
Iobenguane I-123
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| Synonyms |
AdreView (TN)
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| Drug Type |
Small molecular drug
|
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| Indication | Neuroendocrine cancer [ICD10:C7A] | Approved | [1] | ||
| Company |
GE Healthcare
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C8H10IN3
|
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| Canonical SMILES |
C1=CC(=CC(=C1)I)CN=C(N)N
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| InChI |
1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)
|
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| InChIKey |
PDWUPXJEEYOOTR-UHFFFAOYSA-N
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| CAS Number |
CAS 139755-80-9
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7398973, 11111341, 11111342, 11466518, 11467638, 11486016, 14750688, 24278499, 43118198, 47349354, 47573370, 47646555, 47720604, 48169363, 49698519, 50111105, 56219166, 57314158, 77939172, 85788868, 90341658, 99222771, 103113617, 103113618, 103215608, 104321834, 117356661, 117356662, 124749883, 124880479, 125820672, 127320057, 127320058, 127320059, 127320060, 127320061, 127320062, 127320063, 127320064, 127320065, 127320066, 128901924, 135114605, 137102707, 137138944, 142124139, 162916309, 175427085, 179225831, 179235742
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| SuperDrug ATC ID |
V09IX01
|
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| Target and Pathway | |||||
| Target(s) | Sodium-dependent noradrenaline transporter | Target Info | Inhibitor | [2] | |
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | ||||
| WikiPathways | Monoamine Transport | ||||
| NRF2 pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
| References | |||||
| REF 1 | 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 926). | ||||
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