Drug Information

Drug General Information
Drug ID
D02IHW
Former ID
DIB003293
Drug Name
Nepafenac
Synonyms
Nevanac; AHR-9434; AL-6515
Drug Type
Small molecular drug
Indication Osteoarthritis [ICD9: 715; ICD10:M15-M19, M47] Approved [542564], [551186], [551871]
Company
Alcon
Structure
Download
2D MOL

3D MOL
Formula
C15H14N2O2
InChI
InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
InChIKey
QEFAQIPZVLVERP-UHFFFAOYSA-N
CAS Number
CAS 78281-72-8
PubChem Compound ID
151075
PubChem Substance ID
10251001, 14774447, 46227657, 47206867, 49835179, 50070143, 50070890, 50331436, 57347256, 71883489, 85175724, 91749960, 92723396, 99437054, 99443294, 103274041, 104430113, 109693308, 117525219, 118046492, 118314630, 124757120, 124772072, 124896627, 125163924, 125357725, 126617535, 126649074, 126667064, 126731914, 129010085, 135107093, 136949089, 137239515, 137322723, 143496452, 144206538, 152239385, 152258756, 160647601, 160871507, 160967911, 162011723, 162201751, 164175283, 164347474, 164788880, 165235518, 170465203, 172914302
Target and Pathway
Target(s) Cyclooxygenase Target Info Inhibitor [526496], [551871]
References
Ref 542564(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7564).
Ref 5511862005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 526496Topical nepafenac inhibits ocular neovascularization. Invest Ophthalmol Vis Sci. 2003 Jan;44(1):409-15.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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