Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02HCU
|
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| Former ID |
DIB006289
|
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| Drug Name |
WEB-2347
|
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| Drug Type |
Small molecular drug
|
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| Indication | Allergy [ICD9: 995.3; ICD10:T78.4] | Terminated | [1] | ||
| Company |
Boehringer Ingelheim Corp
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C25H28ClN5OS
|
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| Canonical SMILES |
c12c(n3c(nnc3)CN=C2c2c(Cl)cccc2)sc2c1CC(C(=O)N(CCC)CCC)<br />C2
|
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| CAS Number |
CAS 114800-19-0
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001720) | ||||
| REF 2 | WEB 2347: pharmacology of a new very potent and long acting hetrazepinoic PAF-antagonist and its action in repeatedly sensitized guinea-pigs. J Lipid Mediat. 1991 Jul-Aug;4(1):39-44. | ||||
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