Drug Information

Drug General Information
Drug ID
D02GTY
Former ID
DIB013793
Drug Name
Tamibarotene
Synonyms
Tamibarotene (oral, Alzheimer's disease)
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 2/3 [529087], [539714]
Company
Research Foundation Itsuu Laboratory
Structure
Download
2D MOL

3D MOL
Formula
C22H25NO3
InChI
InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
InChIKey
MUTNCGKQJGXKEM-UHFFFAOYSA-N
PubChem Compound ID
108143
Target and Pathway
Target(s) Retinoic acid receptor beta Target Info Modulator [531992]
Retinoic acid receptor alpha Target Info Modulator [531992]
KEGG Pathway Pathways in cancer
Small cell lung cancer
Non-small cell lung cancerhsa05200:Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Pathway Interaction Database Retinoic acid receptors-mediated signaling
Reactome Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Mesodermal Commitment Pathway
Integrated Pancreatic Cancer Pathway
Nuclear ReceptorsWP716:Vitamin A and Carotenoid Metabolism
Adipogenesis
Nuclear Receptors
References
Ref 529087Tamibarotene. Drugs Today (Barc). 2007 Aug;43(8):563-8.
Ref 539714(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2648).
Ref 531992Tamibarotene: a candidate retinoid drug for Alzheimer's disease. Biol Pharm Bull. 2012;35(8):1206-12.

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