Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02DVB
|
||||
| Former ID |
DIB008455
|
||||
| Drug Name |
AGN-191743
|
||||
| Indication | Allergy [ICD9: 995.3; ICD10:T78.4] | Discontinued in Phase 1 | [1] | ||
| Company |
Roche Holding AG
|
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| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003636) | ||||
| REF 2 | US patent application no. 6,274,627, Conjugates of dithiocarbamate disulfides with pharmacologically active agents and uses therefor. | ||||
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