Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02DHU
|
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| Former ID |
DIB008422
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| Drug Name |
SKF-81297
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| Synonyms |
SKF 81297 hydrochloride
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| Drug Type |
Small molecular drug
|
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| Indication | Parkinson's disease [ICD9: 332; ICD10:G20] | Terminated | [1], [2] | ||
| Company |
SmithKline Beecham Pharmaceuticals
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| Structure |
|
Download2D MOL |
|||
| Formula |
C16H16ClNO2
|
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| InChI |
InChI=1S/C16H16ClNO2/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20/h1-5,8,13,18-20H,6-7,9H2
|
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| InChIKey |
GHWJEDJMOVUXEC-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5589359, 7980604, 8151035, 14824803, 24439563, 26756523, 47291339, 47365431, 48259476, 50065113, 50104853, 57320818, 75221142, 85209307, 90341484, 103436438, 103805422, 104297098, 117460298, 124750283, 124881364, 126407017, 127956269, 134222361, 135065772, 135651051, 136352382, 137010203, 162223780, 162903081, 179293662, 179574135, 184587757, 224813544, 226727478, 249801642
|
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| Target and Pathway | |||||
| Target(s) | Dopamine D1 receptor | Target Info | Modulator | [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Morphine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Dopamine receptor mediated signaling pathway | ||||
| PathWhiz Pathway | Dopamine Activation of Neurological Reward System | ||||
| Reactome | Dopamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 938). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004119) | ||||
| REF 3 | Dopamine D1 receptor involvement in the discriminative-stimulus effects of SKF 81297 in squirrel monkeys. J Pharmacol Exp Ther. 1993 Nov;267(2):765-75. | ||||
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