| Drug General Information |
| Drug ID |
D02CZF
|
| Former ID |
DIB015737
|
| Drug Name |
Aderbasib
|
| Synonyms |
INCB-007839; INCB-7839; Sheddase inhibitors (anticancer), Incyte; ADAM inhibitors (oral, cancer), Incyte
|
| Drug Type |
Small molecular drug
|
| Indication |
Breast cancer [ICD9: 174, 175; ICD10:C50]
|
Phase 1/2 |
[1]
|
|---|
| Company |
Incyte Corp
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H28N4O5
|
| Canonical SMILES |
C1CC21CN([C@@H]([C@H](C2)C(=O)NO)C(=O)N1CCN(CC1)c1ccccc<br />1)C(=O)OC
|
| CAS Number |
CAS 791828-58-5
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
ADAM 10 |
Target Info |
Modulator |
|
|---|
| ADAM 17 |
Target Info |
Modulator |
[2]
|
|
KEGG Pathway
|
Alzheimer's disease
|
|
Epithelial cell signaling in Helicobacter pylori infectionhsa04330:Notch signaling pathway
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
NetPath Pathway
|
RANKL Signaling Pathway
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Alzheimer disease-presenilin pathway
|
|
Notch signaling pathway
|
|
Pathway Interaction Database
|
Notch signaling pathway
|
|
Presenilin action in Notch and Wnt signaling
|
|
Posttranslational regulation of adherens junction stability and dissassemblyerbb4_pathway:ErbB4 signaling events
|
|
TNF receptor signaling pathway
|
|
p75(NTR)-mediated signaling
|
|
Reactome
|
Collagen degradation
|
|
Degradation of the extracellular matrix
|
|
Activated NOTCH1 Transmits Signal to the Nucleus
|
|
Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
|
Constitutive Signaling by NOTCH1 t(7
|
|
M1580_K2555) Translocation Mutant
|
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Constitutive Signaling by NOTCH1 HD Domain Mutants
|
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
|
|
NOTCH2 Activation and Transmission of Signal to the Nucleus
|
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EPH-ephrin mediated repulsion of cellsR-HSA-1251985:Nuclear signaling by ERBB4
|
|
Regulated proteolysis of p75NTR
|
|
TNF signaling
|
|
Growth hormone receptor signaling
|
|
WikiPathways
|
Hypertrophy Model
|
|
Copper homeostasis
|
|
Signaling by NOTCH3
|
|
Signaling by NOTCH4
|
|
Signaling by NOTCH2
|
|
Alzheimers DiseaseWP61:Notch Signaling Pathway
|
|
Notch Signaling Pathway
|
|
Growth hormone receptor signaling
|
|
BDNF signaling pathway
|
|
Alzheimers Disease
|
|
Signalling by NGF
|
|
Extrinsic Pathway for Apoptosis
|
| References |
| REF 1 | ClinicalTrials.gov (NCT02141451) INCB7839 With Rituximab After Autologous Hematopoietic Cell Transplantation for Diffuse Large B Cell Non-Hodgkin Lymphoma. U.S. National Institutes of Health. |
|---|
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. |
|---|
