Drug General Information
Drug ID	D02CYZ
Former ID	DNC009297
Drug Name	[2-(Pyrazol-1-yl)ethyl]-bisphosphonic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529758]
Structure		Download 2D MOL 3D MOL
Formula	C5H10N2O6P2
Canonical SMILES	C1=CN(N=C1)CC(P(=O)(O)O)P(=O)(O)O
InChI	1S/C5H10N2O6P2/c8-14(9,10)5(15(11,12)13)4-7-3-1-2-6-7/h1-3,5H,4H2,(H2,8,9,10)(H2,11,12,13)
InChIKey	UUGUSMHQBIUYKQ-UHFFFAOYSA-N
PubChem Compound ID	23043575
Target and Pathway
Target(s)	Farnesyl pyrophosphatesynthetase	Target Info	Inhibitor	[529758]
KEGG Pathway	Terpenoid backbone biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
	Influenza A
	HTLV-I infection
PathWhiz Pathway	Steroid Biosynthesis
Reactome	Cholesterol biosynthesis
	Activation of gene expression by SREBF (SREBP)
WikiPathways	Activation of Gene Expression by SREBP (SREBF)
	SREBP signalling
	Cholesterol Biosynthesis
References
Ref 529758	J Med Chem. 2008 Nov 13;51(21):6800-7. Epub 2008 Oct 21.Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.
Ref 529758	J Med Chem. 2008 Nov 13;51(21):6800-7. Epub 2008 Oct 21.Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.

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