Drug Information

Drug General Information
Drug ID
D02CFE
Former ID
DNC001002
Drug Name
NC-2100
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535014]
Structure
Download
2D MOL

3D MOL
Formula
C20H16N2O3S
Canonical SMILES
C1=CC=C(C=C1)COC2=CC3=NC=C(C=C3C=C2)CC4C(=O)NC(=O)S4
InChI
1S/C20H16N2O3S/c23-19-18(26-20(24)22-19)9-14-8-15-6-7-16(10-17(15)21-11-14)25-12-13-4-2-1-3-5-13/h1-8,10-11,18H,9,12H2,(H,22,23,24)
InChIKey
AZKFGOQRYCSQPK-UHFFFAOYSA-N
CAS Number
CAS 179068-64-5
PubChem Compound ID
9907086
PubChem Substance ID
14877013, 24188332, 45978750, 76246068, 134340271, 137095686, 139617424, 226708976
Target and Pathway
Target(s) Mitochondrial uncoupling protein 2 Target Info Inducer [535014]
Mitochondrial brown fat uncoupling protein 1 Target Info Inducer [535014]
KEGG Pathway PPAR signaling pathway
Huntington's disease
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
WikiPathways Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Electron Transport ChainWP236:Adipogenesis
Electron Transport Chain
References
Ref 535014A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes. 2000 May;49(5):759-67.
Ref 535014A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes. 2000 May;49(5):759-67.

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