Drug General Information
Drug ID	D02AYX
Former ID	DNC010279
Drug Name	2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530608]
Structure		Download 2D MOL 3D MOL
Formula	C11H6N2O3
Canonical SMILES	C1=CC=C2C(=C1)C=C3C(=O)NC(=O)N=C3O2
InChI	1S/C11H6N2O3/c14-9-7-5-6-3-1-2-4-8(6)16-10(7)13-11(15)12-9/h1-5H,(H,12,14,15)
InChIKey	BFMCRAXOACCPEL-UHFFFAOYSA-N
PubChem Compound ID	1403654
Target and Pathway
Target(s)	NAD-dependent deacetylase sirtuin-1	Target Info	Inhibitor	[530608]
KEGG Pathway	FoxO signaling pathway
	AMPK signaling pathway
	Glucagon signaling pathway
	Amphetamine addiction
	MicroRNAs in cancer
PANTHER Pathway	p53 pathway
Pathway Interaction Database	p73 transcription factor network
	Signaling events mediated by HDAC Class III
	E2F transcription factor network
	HIF-2-alpha transcription factor network
	Signaling events mediated by HDAC Class I
	FoxO family signaling
	Regulation of Androgen receptor activity
	Regulation of retinoblastoma protein
Reactome	RORA activates gene expression
	Regulation of HSF1-mediated heat shock response
	Circadian Clock
WikiPathways	Integrated Pancreatic Cancer Pathway
	SREBF and miR33 in cholesterol and lipid homeostasis
	Integrated Breast Cancer Pathway
	SREBP signalling
	Androgen receptor signaling pathway
References
Ref 530608	J Med Chem. 2010 Feb 11;53(3):1407-11.Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
Ref 530608	J Med Chem. 2010 Feb 11;53(3):1407-11.Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.

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