| Drug General Information |
| Drug ID |
D02AKP
|
| Former ID |
DNC007636
|
| Drug Name |
4-methoxy-N'-(2-phenylacetyl)benzohydrazide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H16N2O3
|
| Canonical SMILES |
COC1=CC=C(C=C1)C(=O)NNC(=O)CC2=CC=CC=C2
|
| InChI |
1S/C16H16N2O3/c1-21-14-9-7-13(8-10-14)16(20)18-17-15(19)11-12-5-3-2-4-6-12/h2-10H,11H2,1H3,(H,17,19)(H,18,20)
|
| InChIKey |
BJVRKPCYZSFHDT-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Urokinase-type plasminogen activator |
Target Info |
Inhibitor |
[1]
|
|---|
| Leukocyte elastase |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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NF-kappa B signaling pathway
|
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Complement and coagulation cascades
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Transcriptional misregulation in cancer
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Proteoglycans in cancer
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MicroRNAs in cancerhsa05202:Transcriptional misregulation in cancer
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Systemic lupus erythematosus
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NetPath Pathway
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IL2 Signaling Pathway
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EGFR1 Signaling Pathway
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PANTHER Pathway
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Blood coagulation
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Plasminogen activating cascade
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CCKR signaling map ST
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Pathway Interaction Database
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Beta1 integrin cell surface interactions
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E2F transcription factor network
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Beta3 integrin cell surface interactions
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Osteopontin-mediated events
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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amb2 Integrin signaling
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ATF-2 transcription factor network
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AP-1 transcription factor network
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Beta2 integrin cell surface interactions
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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Beta5 beta6 beta7 and beta8 integrin cell surface interactions
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FGF signaling pathwayupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
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C-MYB transcription factor network
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Reactome
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Dissolution of Fibrin ClotR-HSA-1442490:Collagen degradation
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Degradation of the extracellular matrix
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Activation of Matrix Metalloproteinases
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WikiPathways
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DNA Damage Response (only ATM dependent)
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Senescence and Autophagy in Cancer
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Complement and Coagulation Cascades
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Endochondral Ossification
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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Blood Clotting Cascade
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Dissolution of Fibrin Clot
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Osteopontin SignalingWP2840:Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
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Human Complement System
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Degradation of collagen
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| References |
| REF 1 | J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. |
|---|
