Drug Information

Drug General Information
Drug ID
D02AIM
Former ID
DCL000304
Drug Name
Metoprine
Synonyms
DDMP; Methodichlorophen; Metoprine [USAN]; BW 197 U; BW 1970; BW 197U; BW 50197; BW50197; SK 5265; U 197; BW 50,197; BW 50-197; BW-197U; METOPRINE, METHODICHLOROPHEN; Metoprine (USAN); TCMDC-123931; U-197; 2,4-Diamino-5-(3',4'-dichlorophenyl)-6-methyl pyrimidine; 2,4-Diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine; 5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE-2,4-DIAMINE; 5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine; 5-(3,4-Dichlorphenyl)-6-methyl-2,4-pyrimidindiamin
Drug Type
Small molecular drug
Indication Advanced cancers [ICD9: 140-229; ICD10:C00-C96] Phase 2 [523875], [542436]
Company
Werkheiser
Structure
Download
2D MOL

3D MOL
Formula
C11H10Cl2N4
InChI
InChI=1S/C11H10Cl2N4/c1-5-9(10(14)17-11(15)16-5)6-2-3-7(12)8(13)4-6/h2-4H,1H3,(H4,14,15,16,17)
InChIKey
VQJHOPSWBGJHQS-UHFFFAOYSA-N
CAS Number
CAS 7761-45-7
PubChem Compound ID
24466
PubChem Substance ID
73253, 82389, 602547, 7611890, 7847375, 7886431, 8026862, 8136917, 8167867, 11445962, 11446882, 14848327, 24714896, 29291534, 46393826, 46504679, 47217117, 50035975, 50971542, 57331733, 84974635, 85858390, 92763928, 103224661, 103955731, 104359914, 117418166, 124633328, 125434045, 126729571, 129512013, 134224754, 134338960, 134339850, 134990138, 137184701, 137241183, 142971122, 152133986, 160967647, 163884598, 164763044, 170466776, 178103984, 179151147, 187071961, 198935081, 223681386, 226395808, 241145375
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [536216]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 523875ClinicalTrials.gov (NCT01579110) Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia.. U.S. National Institutes of Health.
Ref 542436(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7412).
Ref 536216Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. Epub 2006 Apr 13.

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