Drug Information

Drug General Information
Drug ID
D01ZXW
Former ID
DCL000149
Drug Name
Lintitript
Synonyms
SR 27897; SR 27897B; SR27897; SR-27897; SR-27897B; 1-((2-(4-(2-Chlorophenyl)thiazol-2-yl)aminocarbonyl)indolyl)acetic acid; 2-((4-(o-Chlorophenyl)-2-thiazolyl)carbamoyl)indole-1-acetic acid; 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]acetic acid
Drug Type
Small molecular drug
Indication Pancreatic cancer; Obesity [ICD9: 140-229, 157, 278; ICD10:C25, E66] Discontinued in Phase 2 [543282], [545822]
Therapeutic Class
Anticancer Agents
Company
Sanofi-aventis
Structure
Download
2D MOL

3D MOL
Formula
C20H14ClN3O3S
InChI
InChI=1S/C20H14ClN3O3S/c21-14-7-3-2-6-13(14)15-11-28-20(22-15)23-19(27)17-9-12-5-1-4-8-16(12)24(17)10-18(25)26/h1-9,11H,10H2,(H,25,26)(H,22,23,27)
InChIKey
ILNRQFBVVQUOLP-UHFFFAOYSA-N
CAS Number
CAS 136381-85-6
PubChem Compound ID
122077
PubChem Substance ID
7980659, 10239927, 14806438, 29302530, 47583729, 48105187, 50064374, 50112865, 52854802, 57339937, 85209316, 85787643, 103555631, 104414961, 123121570, 124893352, 128185397, 134338829, 135079374, 135650524, 135697565, 136350276, 142014418, 144206134, 162023385, 162312829, 163304545, 170466345, 175426876, 175612460, 176223166, 179149861, 198988061, 204359779, 226414792, 241375812, 252156343, 252159988
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Antagonist [535989], [536755]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543282(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 890).
Ref 545822Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004912)
Ref 535989A novel role for cholecystokinin: regulation of mesenteric vascular resistance. Regul Pept. 2004 Sep 15;121(1-3):145-53.
Ref 536755A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin. Br J Pharmacol. 2008 Jul;154(5):1009-15. Epub 2008 Apr 21.

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