Drug Information

Drug General Information
Drug ID
D01ZSF
Former ID
DNC009019
Drug Name
GR-218231
Drug Type
Small molecular drug
Indication Discovery agent Terminated [542030], [546446]
Structure
Download
2D MOL

3D MOL
Formula
C24H33NO3S
InChI
InChI=1S/C24H33NO3S/c1-4-14-25(15-5-2)22-9-8-20-16-19(6-7-21(20)17-22)18-29(26,27)24-12-10-23(28-3)11-13-24/h6-7,10-13,16,22H,4-5,8-9,14-15,17-18H2,1-3H3/t22-/m1/s1
InChIKey
HUXFXXWYIRBVJR-JOCHJYFZSA-N
PubChem Compound ID
5312124
PubChem Substance ID
7979647, 11056890, 14757950, 14757951, 39341744, 47359942, 48179758, 57309643, 57359518, 80368117, 103366356, 114157933, 134374355, 135328872, 135650317, 162247313, 184538762, 226927600, 252320644
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [529862]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 542030(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 70).
Ref 546446Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008161)
Ref 529862Bioorg Med Chem. 2009 Jan 15;17(2):758-66. Epub 2008 Nov 24.Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II.

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