Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01ZDR
|
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| Former ID |
DIB011410
|
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| Drug Name |
FR-208419
|
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| Synonyms |
IDDB16886
|
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| Drug Type |
Small molecular drug
|
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| Indication | Dyspepsia [ICD9: 536.8; ICD10:K30] | Terminated | [1] | ||
| Company |
Fujisawa Pharmaceutical Co Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C28H34N4O3
|
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| Canonical SMILES |
N1(c2c(C(=N[C@H](NC(=O)Nc3cc(ccc3)C)C1)CC)cccc2C)CC(=O)<br />C1CCCCC1
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Gastrin/cholecystokinin type B receptor | Target Info | Modulator | [2] | |
| Cholecystokinin receptor type A | Target Info | Modulator | [2] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretionhsa04020:Calcium signaling pathway | |||||
| Insulin secretion | |||||
| Pancreatic secretion | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010485) | ||||
| REF 2 | Dual CCK-A and CCK-B receptor antagonists (II). Preparation and structure activity relationships of 5-alkyl-9-methyl-1,4-benzodiazepines and discovery of FR208419. Chem Pharm Bull (Tokyo). 2000 Jan;48(1):1-15. | ||||
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