Drug General Information
Drug ID	D01ZDR
Former ID	DIB011410
Drug Name	FR-208419
Synonyms	IDDB16886
Drug Type	Small molecular drug
Indication	Dyspepsia [ICD9: 536.8; ICD10:K30]		Terminated	[546824]
Company	Fujisawa Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C28H34N4O3
Canonical SMILES	N1(c2c(C(=N[C@H](NC(=O)Nc3cc(ccc3)C)C1)CC)cccc2C)CC(=O)<br />C1CCCCC1
PubChem Compound ID	6918392
Target and Pathway
Target(s)	Gastrin/cholecystokinin type B receptor	Target Info	Modulator	[525711]
	Cholecystokinin receptor type A	Target Info	Modulator	[525711]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretionhsa04020:Calcium signaling pathway
	Insulin secretion
	Pancreatic secretion
PANTHER Pathway	CCKR signaling map ST
PathWhiz Pathway	Gastric Acid Production
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
	Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 546824	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010485)
Ref 525711	Dual CCK-A and CCK-B receptor antagonists (II). Preparation and structure activity relationships of 5-alkyl-9-methyl-1,4-benzodiazepines and discovery of FR208419. Chem Pharm Bull (Tokyo). 2000 Jan;48(1):1-15.

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