Drug General Information
Drug ID
D01XWG
Former ID
DAP000788
Drug Name
Daunorubicin
Synonyms
Acetyladriamycin; Anthracyline; Cerubidin; Cerubidine; Daunamycin; Daunarubicinum; DaunoXome; Daunoblastin; Daunoblastine; Daunomycin; Daunorrubicina; Daunorubicine; Daunorubicinum; Rubidomycin; Rubomycin; Antibiotics from Streptomyces coeruleorubidus; DAUNORUBICIN HCL; Leukaemomycin C; Rubomycin C; DM1; FI 6339; FI6339; RP 13057; Dauno-Rubidomycine; DaunoXome (TN); Daunorubicin (INN); Daunorubicin (liposomal); Daunorubicin [INN:BAN]; Daunorubicin, Hydrochloride; Daunorubicinum [INN-Latin]; VS-103; (+)-Daunomycin; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-(methyloxy)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside; (7S,9R)-9-Acetyl-7-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-oxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
Drug Type
Small molecular drug
Indication Acute myeloid leukemia [ICD9: 205; ICD10:C92.0] Approved [536361], [542069]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL

Formula
C27H29NO10
InChI
InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1
InChIKey
STQGQHZAVUOBTE-VGBVRHCVSA-N
CAS Number
CAS 20830-81-3
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:41977
SuperDrug ATC ID
L01DB02
SuperDrug CAS ID
cas=020830813
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator [556264]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542069(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7063).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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