Drug Information
Drug General Information | |||||
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Drug ID |
D01XBA
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Former ID |
DIB013176
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Drug Name |
Raloxifene
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Synonyms |
Raloxifene (extended-release, CDT)
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Drug Type |
Small molecular drug
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Company |
SCOLR Pharma Inc
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Structure |
Download2D MOL |
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Formula |
C28H27NO4S
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InChI |
InChI=1S/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,30-31H,1-3,14-17H2
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InChIKey |
GZUITABIAKMVPG-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
9437, 831017, 5392969, 7890214, 7980482, 8153100, 11111733, 11111734, 11364773, 11367335, 11369897, 11372937, 11375497, 11378062, 11466890, 11468010, 11486560, 14834427, 24277274, 26705265, 29224106, 46506514, 46519463, 47213213, 47365304, 47662399, 47810849, 47810850, 48035235, 48185088, 48259344, 48416509, 49698670, 50065297, 50105675, 50139488, 50898374, 53788657, 56310724, 56312953, 56313701, 56352882, 56427219, 57322575, 90341181, 91148450, 92308782, 93165668, 93166953, 96025151
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Target and Pathway | |||||
Target(s) | Estrogen receptor | Target Info | Modulator | [543898] | |
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
Signaling events mediated by HDAC Class II | |||||
Plasma membrane estrogen receptor signaling | |||||
LKB1 signaling events | |||||
Regulation of Telomerase | |||||
ATF-2 transcription factor network | |||||
AP-1 transcription factor network | |||||
FOXM1 transcription factor network | |||||
Validated nuclear estrogen receptor alpha network | |||||
Signaling mediated by p38-alpha and p38-beta | |||||
FOXA1 transcription factor network | |||||
References | |||||
Ref 523817 | ClinicalTrials.gov (NCT01544894) Clinical Study of Raloxifene and Strontium Ranelate in Postmenopausal Osteoporosis. U.S. National Institutes of Health. | ||||
Ref 539863 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2820). | ||||
Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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