Drug General Information
Drug ID	D01WIH
Former ID	DNC004683
Drug Name	(4-Fluoro-phenyl)-(9H-purin-6-yl)-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527421]
Structure		Download 2D MOL 3D MOL
Formula	C11H8FN5
Canonical SMILES	C1=CC(=CC=C1NC2=NC=NC3=C2NC=N3)F
InChI	1S/C11H8FN5/c12-7-1-3-8(4-2-7)17-11-9-10(14-5-13-9)15-6-16-11/h1-6H,(H2,13,14,15,16,17)
InChIKey	SCRHVVOELSYCSO-UHFFFAOYSA-N
PubChem Compound ID	51998
Target and Pathway
Target(s)	Rho-associated protein kinase 1	Target Info	Inhibitor	[527421]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Chemokine signaling pathway
	Sphingolipid signaling pathway
	Vascular smooth muscle contraction
	TGF-beta signaling pathway
	Axon guidance
	Focal adhesion
	Platelet activation
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton
	Oxytocin signaling pathway
	Pathogenic Escherichia coli infection
	Shigellosis
	Salmonella infection
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
PANTHER Pathway	Cytoskeletal regulation by Rho GTPase
	Inflammation mediated by chemokine and cytokine signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	Signaling events mediated by PRL
	RhoA signaling pathway
	Noncanonical Wnt signaling pathway
	EPHB forward signaling
	Thromboxane A2 receptor signaling
	PAR4-mediated thrombin signaling events
	amb2 Integrin signaling
	Integrins in angiogenesis
	EPHA forward signaling
	Stabilization and expansion of the E-cadherin adherens junction
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling events
	N-cadherin signaling events
Reactome	Apoptotic cleavage of cellular proteins
	EPHB-mediated forward signaling
	EPHA-mediated growth cone collapse
	G alpha (12/13) signalling events
	Sema4D induced cell migration and growth-cone collapse
	VEGFA-VEGFR2 Pathway
	RHO GTPases Activate ROCKs
WikiPathways	G13 Signaling Pathway
	Regulation of Actin Cytoskeleton
	EGF/EGFR Signaling Pathway
	TGF beta Signaling Pathway
	Focal Adhesion
	JAK/STAT
	AGE/RAGE pathway
	Pathogenic Escherichia coli infection
	Regulation of Microtubule Cytoskeleton
	Leptin signaling pathway
	Semaphorin interactions
	Integrin-mediated Cell Adhesion
	GPCR downstream signaling
	Apoptotic execution phase
	MicroRNAs in cardiomyocyte hypertrophy
	Androgen receptor signaling pathway
References
Ref 527421	J Med Chem. 2005 Feb 10;48(3):710-22.Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors.
Ref 527421	J Med Chem. 2005 Feb 10;48(3):710-22.Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors.

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