| Drug General Information |
| Drug ID |
D01WIH
|
| Former ID |
DNC004683
|
| Drug Name |
(4-Fluoro-phenyl)-(9H-purin-6-yl)-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H8FN5
|
| Canonical SMILES |
C1=CC(=CC=C1NC2=NC=NC3=C2NC=N3)F
|
| InChI |
1S/C11H8FN5/c12-7-1-3-8(4-2-7)17-11-9-10(14-5-13-9)15-6-16-11/h1-6H,(H2,13,14,15,16,17)
|
| InChIKey |
SCRHVVOELSYCSO-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Rho-associated protein kinase 1 |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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Sphingolipid signaling pathway
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Vascular smooth muscle contraction
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TGF-beta signaling pathway
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Axon guidance
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Focal adhesion
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Platelet activation
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Leukocyte transendothelial migration
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Regulation of actin cytoskeleton
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Oxytocin signaling pathway
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Pathogenic Escherichia coli infection
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Shigellosis
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Salmonella infection
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Pathways in cancer
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Proteoglycans in cancer
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MicroRNAs in cancer
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PANTHER Pathway
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Cytoskeletal regulation by Rho GTPase
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Inflammation mediated by chemokine and cytokine signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Signaling events mediated by PRL
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RhoA signaling pathway
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Noncanonical Wnt signaling pathway
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EPHB forward signaling
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Thromboxane A2 receptor signaling
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PAR4-mediated thrombin signaling events
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amb2 Integrin signaling
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Integrins in angiogenesis
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EPHA forward signaling
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Stabilization and expansion of the E-cadherin adherens junction
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling events
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N-cadherin signaling events
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Reactome
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Apoptotic cleavage of cellular proteins
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EPHB-mediated forward signaling
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EPHA-mediated growth cone collapse
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G alpha (12/13) signalling events
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Sema4D induced cell migration and growth-cone collapse
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VEGFA-VEGFR2 Pathway
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RHO GTPases Activate ROCKs
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WikiPathways
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G13 Signaling Pathway
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Regulation of Actin Cytoskeleton
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EGF/EGFR Signaling Pathway
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TGF beta Signaling Pathway
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Focal Adhesion
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JAK/STAT
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AGE/RAGE pathway
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Pathogenic Escherichia coli infection
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Regulation of Microtubule Cytoskeleton
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Leptin signaling pathway
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Semaphorin interactions
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Integrin-mediated Cell Adhesion
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GPCR downstream signaling
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Apoptotic execution phase
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MicroRNAs in cardiomyocyte hypertrophy
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Androgen receptor signaling pathway
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| References |
| REF 1 | J Med Chem. 2005 Feb 10;48(3):710-22.Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
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