| Drug General Information |
| Drug ID |
D01WAI
|
| Former ID |
DNC003810
|
| Drug Name |
DEBROMOHYMENIALDISINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H11N5O2
|
| Canonical SMILES |
C1CNC(=O)C2=C(C1=C3C(=O)N=C(N3)N)C=CN2
|
| InChI |
1S/C11H11N5O2/c12-11-15-8(10(18)16-11)6-2-4-14-9(17)7-5(6)1-3-13-7/h1,3,13H,2,4H2,(H,14,17)(H3,12,15,16,18)/b8-6-
|
| InChIKey |
JYRJOQGKGMHTOO-VURMDHGXSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Mitogen-activated protein kinase 1 |
Target Info |
Inhibitor |
[1]
|
|---|
| mRNA of RAF proto-oncogene serine/threonine-protein kinase |
Target Info |
Inhibitor |
[2]
|
| Serine/threonine-protein kinase Chk2 |
Target Info |
Inhibitor |
[1]
|
| Serine/threonine-protein kinase Chk1 |
Target Info |
Inhibitor |
[1]
|
| Dual specificity mitogen-activated protein kinase kinase 1 |
Target Info |
Inhibitor |
[2]
|
|
BioCyc Pathway
|
MAP kinase cascade
|
|
KEGG Pathway
|
MAPK signaling pathway
|
|
ErbB signaling pathway
|
|
Ras signaling pathway
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Rap1 signaling pathway
|
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cGMP-PKG signaling pathway
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cAMP signaling pathway
|
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Chemokine signaling pathway
|
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HIF-1 signaling pathway
|
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FoxO signaling pathway
|
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Sphingolipid signaling pathway
|
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Oocyte meiosis
|
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mTOR signaling pathway
|
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PI3K-Akt signaling pathway
|
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Adrenergic signaling in cardiomyocytes
|
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Vascular smooth muscle contraction
|
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Dorso-ventral axis formation
|
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TGF-beta signaling pathway
|
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Axon guidance
|
|
VEGF signaling pathway
|
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Osteoclast differentiation
|
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Focal adhesion
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Adherens junction
|
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Gap junction
|
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Signaling pathways regulating pluripotency of stem cells
|
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Platelet activation
|
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Toll-like receptor signaling pathway
|
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NOD-like receptor signaling pathway
|
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Natural killer cell mediated cytotoxicity
|
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T cell receptor signaling pathway
|
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B cell receptor signaling pathway
|
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Fc epsilon RI signaling pathway
|
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Fc gamma R-mediated phagocytosis
|
|
TNF signaling pathway
|
|
Circadian entrainment
|
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Long-term potentiation
|
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Neurotrophin signaling pathway
|
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Retrograde endocannabinoid signaling
|
|
Glutamatergic synapse
|
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Cholinergic synapse
|
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Serotonergic synapse
|
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Long-term depression
|
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Regulation of actin cytoskeleton
|
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Insulin signaling pathway
|
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GnRH signaling pathway
|
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Progesterone-mediated oocyte maturation
|
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Estrogen signaling pathway
|
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Melanogenesis
|
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Type II diabetes mellitus
|
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Aldosterone-regulated sodium reabsorption
|
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Alzheimer's disease
|
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Prion diseases
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Alcoholism
|
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Shigellosis
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Salmonella infection
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Pertussis
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Leishmaniasis
|
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
|
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Hepatitis C
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Hepatitis B
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Influenza A
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Pathways in cancer
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Viral carcinogenesis
|
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Proteoglycans in cancer
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MicroRNAs in cancer
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Colorectal cancer
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Renal cell carcinoma
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Pancreatic cancer
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Endometrial cancer
|
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Glioma
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Prostate cancer
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Thyroid cancer
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Melanoma
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Bladder cancer
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Chronic myeloid leukemia
|
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Acute myeloid leukemia
|
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Non-small cell lung cancer
|
|
Central carbon metabolism in cancer
|
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Choline metabolism in cancerhsa04010:MAPK signaling pathway
|
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Choline metabolism in cancerhsa04110:Cell cycle
|
|
p53 signaling pathway
|
|
HTLV-I infectionhsa04110:Cell cycle
|
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HTLV-I infection
|
|
Viral carcinogenesishsa04010:MAPK signaling pathway
|
|
Choline metabolism in cancer
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
|
|
IL2 Signaling Pathway
|
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EGFR1 Signaling PathwayNetPath_25:FSH Signaling Pathway
|
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TGF_beta_Receptor Signaling Pathway
|
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PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Angiogenesis
|
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Apoptosis signaling pathway
|
|
B cell activation
|
|
EGF receptor signaling pathway
|
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Endothelin signaling pathway
|
|
FGF signaling pathway
|
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Inflammation mediated by chemokine and cytokine signaling pathway
|
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Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
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Interferon-gamma signaling pathway
|
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Interleukin signaling pathway
|
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PDGF signaling pathway
|
|
Parkinson disease
|
|
TGF-beta signaling pathway
|
|
T cell activation
|
|
VEGF signaling pathway
|
|
Ras Pathway
|
|
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
|
|
CCKR signaling map STP00005:Angiogenesis
|
|
Integrin signalling pathway
|
|
Toll receptor signaling pathway
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
Fc-epsilon receptor I signaling in mast cells
|
|
Endothelins
|
|
BCR signaling pathway
|
|
Signaling events mediated by PRL
|
|
ErbB4 signaling events
|
|
GMCSF-mediated signaling events
|
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
S1P3 pathway
|
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EPHB forward signaling
|
|
Osteopontin-mediated events
|
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S1P4 pathway
|
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Presenilin action in Notch and Wnt signaling
|
|
TRAIL signaling pathway
|
|
CDC42 signaling events
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
Angiopoietin receptor Tie2-mediated signaling
|
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S1P1 pathway
|
|
Regulation of Telomerase
|
|
Netrin-mediated signaling events
|
|
Glucocorticoid receptor regulatory network
|
|
Arf6 downstream pathway
|
|
mTOR signaling pathway
|
|
Class IB PI3K non-lipid kinase events
|
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IL2-mediated signaling events
|
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EGF receptor (ErbB1) signaling pathway
|
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Ras signaling in the CD4+ TCR pathway
|
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Ceramide signaling pathway
|
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Integrins in angiogenesis
|
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IFN-gamma pathway
|
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ErbB1 downstream signaling
|
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ATF-2 transcription factor network
|
|
ErbB2/ErbB3 signaling events
|
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BMP receptor signaling
|
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ALK1 signaling events
|
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PDGFR-beta signaling pathway
|
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Neurotrophic factor-mediated Trk receptor signaling
|
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Syndecan-1-mediated signaling events
|
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Retinoic acid receptors-mediated signaling
|
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Nongenotropic Androgen signaling
|
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CXCR3-mediated signaling events
|
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VEGFR1 specific signals
|
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Regulation of cytoplasmic and nuclear SMAD2/3 signaling
|
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Signaling events mediated by VEGFR1 and VEGFR2
|
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Syndecan-2-mediated signaling events
|
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Cellular roles of Anthrax toxin
|
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S1P2 pathway
|
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Trk receptor signaling mediated by the MAPK pathway
|
|
Downstream signaling in naï
|
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VEGFR3 signaling in lymphatic endothelium
|
|
Alpha-synuclein signaling
|
|
FGF signaling pathway
|
|
Signaling events mediated by focal adhesion kinasefcer1pathway:Fc-epsilon receptor I signaling in mast cells
|
|
SHP2 signaling
|
|
IGF1 pathway
|
|
p38 signaling mediated by MAPKAP kinases
|
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Internalization of ErbB1
|
|
Signaling events mediated by Stem cell factor receptor (c-Kit)
|
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Class I PI3K signaling events mediated by Akt
|
|
Regulation of retinoblastoma protein
|
|
Signaling events mediated by focal adhesion kinaseatm_pathway:ATM pathway
|
|
FOXM1 transcription factor network
|
|
p53 pathway
|
|
PLK3 signaling eventsfanconi_pathway:Fanconi anemia pathway
|
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p73 transcription factor network
|
|
ATR signaling pathway
|
|
Circadian rhythm pathway
|
|
p53 pathwayfcer1pathway:Fc-epsilon receptor I signaling in mast cells
|
|
Hedgehog signaling events mediated by Gli proteins
|
|
Signaling events mediated by focal adhesion kinase
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Insulin SignallingPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Insulin Signalling
|
|
Reactome
|
RAF-independent MAPK1/3 activation
|
|
MAPK1 (ERK2) activation
|
|
Golgi Cisternae Pericentriolar Stack Reorganization
|
|
ERK/MAPK targets
|
|
Regulation of actin dynamics for phagocytic cup formation
|
|
Oxidative Stress Induced Senescence
|
|
Senescence-Associated Secretory Phenotype (SASP)
|
|
Oncogene Induced Senescence
|
|
FCERI mediated MAPK activation
|
|
Regulation of HSF1-mediated heat shock response
|
|
NCAM signaling for neurite out-growth
|
|
Recycling pathway of L1
|
|
CREB phosphorylation through the activation of Ras
|
|
Activation of the AP-1 family of transcription factors
|
|
Thrombin signalling through proteinase activated receptors (PARs)
|
|
Negative regulation of FGFR1 signaling
|
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Negative regulation of FGFR2 signaling
|
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Negative regulation of FGFR3 signaling
|
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Negative regulation of FGFR4 signaling
|
|
RHO GTPases Activate WASPs and WAVEs
|
|
RAF/MAP kinase cascade
|
|
MAP2K and MAPK activation
|
|
Negative feedback regulation of MAPK pathway
|
|
Negative regulation of MAPK pathway
|
|
Signal attenuation
|
|
Advanced glycosylation endproduct receptor signaling
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Growth hormone receptor signalingR-HSA-2672351:Stimuli-sensing channels
|
|
GP1b-IX-V activation signalling
|
|
CD209 (DC-SIGN) signaling
|
|
RAF activation
|
|
Negative regulation of MAPK pathwayR-HSA-5693565:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
|
|
G2/M DNA damage checkpoint
|
|
Ubiquitin Mediated Degradation of Phosphorylated Cdc25AR-HSA-176187:Activation of ATR in response to replication stress
|
|
Processing of DNA double-strand break ends
|
|
Presynaptic phase of homologous DNA pairing and strand exchange
|
|
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
|
|
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-110056:MAPK3 (ERK1) activation
|
|
Uptake and function of anthrax toxins
|
|
MAP3K8 (TPL2)-dependent MAPK1/3 activation
|
|
WikiPathways
|
Toll-like receptor signaling pathway
|
|
Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
Serotonin HTR1 Group and FOS Pathway
|
|
Vitamin A and Carotenoid Metabolism
|
|
DNA Damage Response (only ATM dependent)
|
|
TCR Signaling Pathway
|
|
ErbB Signaling Pathway
|
|
Hypothetical Network for Drug Addiction
|
|
Senescence and Autophagy in Cancer
|
|
EPO Receptor Signaling
|
|
Regulation of Actin Cytoskeleton
|
|
IL-2 Signaling Pathway
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
MAPK Cascade
|
|
IL-4 Signaling Pathway
|
|
MAPK Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
IL-6 signaling pathway
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
Kit receptor signaling pathway
|
|
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
|
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
IL-3 Signaling Pathway
|
|
Bladder Cancer
|
|
Cardiac Hypertrophic Response
|
|
MAP kinase activation in TLR cascade
|
|
Fc epsilon receptor (FCERI) signaling
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
RAF/MAP kinase cascade
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Structural Pathway of Interleukin 1 (IL-1)
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
|
EBV LMP1 signaling
|
|
Signal Transduction of S1P Receptor
|
|
Nifedipine Activity
|
|
Aryl Hydrocarbon Receptor
|
|
PDGF Pathway
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Spinal Cord Injury
|
|
BDNF signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Corticotropin-releasing hormone
|
|
Interleukin-11 Signaling Pathway
|
|
AGE/RAGE pathway
|
|
TNF alpha Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Prostate Cancer
|
|
Signaling Pathways in Glioblastoma
|
|
TSLP Signaling Pathway
|
|
IL-9 Signaling Pathway
|
|
Endothelin Pathways
|
|
IL17 signaling pathway
|
|
Alzheimers Disease
|
|
IL-7 Signaling Pathway
|
|
TWEAK Signaling Pathway
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Integrated Breast Cancer Pathway
|
|
Opioid Signalling
|
|
IL-1 signaling pathway
|
|
Thrombin signalling through proteinase activated receptors (PARs)
|
|
Signaling by FGFR
|
|
Integrin-mediated Cell Adhesion
|
|
L1CAM interactions
|
|
Advanced glycosylation endproduct receptor signaling
|
|
Heart Development
|
|
Type II diabetes mellitus
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Angiogenesis
|
|
Physiological and Pathological Hypertrophy of the Heart
|
|
Regulation of toll-like receptor signaling pathway
|
|
Osteopontin Signaling
|
|
IL-5 Signaling PathwayWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
Extracellular vesicle-mediated signaling in recipient cells
|
|
Iron uptake and transport
|
|
Retinoblastoma (RB) in Cancer
|
|
Rap1 signalling
|
|
GP1b-IX-V activation signalling
|
|
IL-5 Signaling PathwayWP707:DNA Damage Response
|
|
ATM Signaling Pathway
|
|
Integrated Cancer pathway
|
|
Cell Cycle
|
|
miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
|
|
Signaling by SCF-KIT
|
|
Cell Cycle Checkpoints
|
|
miRNA Regulation of DNA Damage ResponseWP75:Toll-like receptor signaling pathway
|
|
Estrogen signaling pathway
|
|
Focal Adhesion
|
|
TSH signaling pathway
|
|
IL-5 Signaling Pathway
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2004 Aug 16;14(16):4319-21.Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine. |
|---|
| REF 2 | J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). |
|---|
