Drug Information

Drug General Information
Drug ID
D01VVM
Former ID
DIB021066
Drug Name
TNP-ATP
Synonyms
2',3'-O-(2,4,6-trinitrophenyl)-ATP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467662]
Structure
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2D MOL
Formula
C16H12N8O19P3-
InChI
InChI=1S/C16H13N8O19P3/c17-13-10-14(19-4-18-13)21(5-20-10)15-12-11(7(39-15)3-38-45(34,35)43-46(36,37)42-44(31,32)33)40-16(41-12)8(23(27)28)1-6(22(25)26)2-9(16)24(29)30/h1-2,4-5,8,10,17H,3H2,(H4,31,32,33,34,35,36,37)/p-1
InChIKey
NHXFSKZBEIIARS-UHFFFAOYSA-M
PubChem Compound ID
3035228
PubChem Substance ID
36078755, 50065739, 57353057, 78843232, 111638451, 134222757, 135075167, 178101141
Target and Pathway
Target(s) P2X1 Target Info Antagonist [534640]
P2X purinoceptor 3 Target Info Antagonist [534640]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
References
Ref 467662(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4324).
Ref 534640Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol. 1998 Jun;53(6):969-73.

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