Drug Information
Drug General Information | |||||
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Drug ID |
D01TDV
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Former ID |
DIB019176
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Drug Name |
compound 1
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C25H28N6O2
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InChI |
InChI=1S/C25H28N6O2/c1-29-12-14-30(15-13-29)22-10-5-19(16-23(22)33-3)27-24-11-4-18-17-26-31(25(18)28-24)20-6-8-21(32-2)9-7-20/h4-11,16-17H,12-15H2,1-3H3,(H,27,28)
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InChIKey |
LZQFMCFJCXQTTG-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | mRNA of Aurora B | Target Info | Inhibitor | [532161] | |
STK33 | Target Info | Inhibitor | [531549] | ||
Protein kinase A | Target Info | Inhibitor | [532161] | ||
Pathway Interaction Database | Aurora B signaling | ||||
Signaling by Aurora kinases | |||||
Aurora C signaling | |||||
FOXM1 transcription factor network | |||||
Aurora A signaling | |||||
References | |||||
Ref 531549 | STK33 kinase activity is nonessential in KRAS-dependent cancer cells. Cancer Res. 2011 Sep 1;71(17):5818-26. | ||||
Ref 532161 | A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. Epub 2012 Oct 22. | ||||
Ref 531549 | STK33 kinase activity is nonessential in KRAS-dependent cancer cells. Cancer Res. 2011 Sep 1;71(17):5818-26. | ||||
Ref 532161 | A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. Epub 2012 Oct 22. |
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