Drug General Information
Drug ID
D01SRS
Former ID
DNC004986
Drug Name
3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527414]
Structure
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2D MOL

3D MOL

Formula
C10H12N2O2
Canonical SMILES
CC1CC2=C(CN1)C=C(C=C2)[N+](=O)[O-]
InChI
1S/C10H12N2O2/c1-7-4-8-2-3-10(12(13)14)5-9(8)6-11-7/h2-3,5,7,11H,4,6H2,1H3
InChIKey
OTVSEAHLIUCIKT-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Alpha-2A adrenergic receptor Target Info Inhibitor [527414]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 527414Bioorg Med Chem Lett. 2005 Feb 15;15(4):1143-7.Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.
Ref 527414Bioorg Med Chem Lett. 2005 Feb 15;15(4):1143-7.Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.

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