Drug General Information
Drug ID	D01QAR
Former ID	DIB010461
Drug Name	LY-221068
Drug Type	Small molecular drug
Indication	Arthritis [ICD9: 710-719; ICD10:M00-M25]		Terminated	[545172]
Company	Eli Lilly & Co
Structure		Download 2D MOL 3D MOL
Formula	C20H30N2O2S
Canonical SMILES	N1(C(=O)/C(=C/c2cc(c(c(C(C)(C)C)c2)O)C(C)(C)C)/SC1)N(C)<br />C
CAS Number	CAS 132392-39-3
PubChem Compound ID	6439333
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[529094]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 545172	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002348)
Ref 529094	Anti-inflammatory effects of LY221068 and LY269415. Agents Actions. 1991 Sep;34(1-2):100-2.

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