Drug General Information
Drug ID	D01QAR
Former ID	DIB010461
Drug Name	LY-221068
Drug Type	Small molecular drug
Indication	Arthritis [ICD9: 710-719; ICD10:M00-M25]		Terminated	[1]
Company	Eli Lilly & Co
Structure		Download 2D MOL 3D MOL
Formula	C20H30N2O2S
Canonical SMILES	N1(C(=O)/C(=C/c2cc(c(c(C(C)(C)C)c2)O)C(C)(C)C)/SC1)N(C)<br />C
CAS Number	CAS 132392-39-3
PubChem Compound ID	6439333
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[2]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
REF 1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002348)
REF 2	Anti-inflammatory effects of LY221068 and LY269415. Agents Actions. 1991 Sep;34(1-2):100-2.

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