| Drug General Information |
| Drug ID |
D01ODR
|
| Former ID |
DIB018765
|
| Drug Name |
AG 1024
|
| Synonyms |
tyrphostin AG 1024; AG-1024; AG1024
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C14H13BrN2O
|
| InChI |
InChI=1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3
|
| InChIKey |
ABBADGFSRBWENF-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
842085, 5597980, 8151398, 14825445, 26758176, 29221227, 48334273, 57309763, 57321113, 77697430, 85787117, 99302609, 103071496, 103080977, 104299445, 117388823, 121367725, 124289246, 124659184, 126407273, 135321857, 135727819, 136348778, 136367455, 138164445, 152159567, 152344569, 162011619, 162205201, 162247721, 162631860, 163336445, 163620694, 163686008, 163688652, 164041976, 172112209, 174006534, 174530213, 178102535, 179148359, 184815471, 215785827, 223387069, 223544962, 223705282, 224799545, 235475733, 251962945, 252214682
|
| Target and Pathway |
| Target(s) |
mRNA of Insulin-like growth factor 1 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
HIF-1 signaling pathway
|
|
FoxO signaling pathway
|
|
Oocyte meiosis
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
AMPK signaling pathway
|
|
Focal adhesion
|
|
Adherens junction
|
|
Signaling pathways regulating pluripotency of stem cells
|
|
Long-term depression
|
|
Ovarian steroidogenesis
|
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Progesterone-mediated oocyte maturation
|
|
Pathways in cancer
|
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Transcriptional misregulation in cancer
|
|
Proteoglycans in cancer
|
|
Glioma
|
|
Prostate cancer
|
|
Melanoma
|
|
PANTHER Pathway
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
|
Pathway Interaction Database
|
Plasma membrane estrogen receptor signaling
|
|
SHP2 signaling
|
|
IGF1 pathway
|
|
Posttranslational regulation of adherens junction stability and dissassembly
|
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Integrins in angiogenesis
|
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Stabilization and expansion of the E-cadherin adherens junction
|
|
Reactome
|
IRS-related events triggered by IGF1R
|
|
SHC-related events triggered by IGF1R
|
|
WikiPathways
|
Senescence and Autophagy in Cancer
|
|
Insulin Signaling
|
|
Endochondral Ossification
|
|
Focal Adhesion
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
|
Apoptosis
|
|
Signaling Pathways in Glioblastoma
|
|
TSH signaling pathway
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
| References |
| REF 1 | Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr;138(4):1427-33. |
|---|
