Drug General Information
Drug ID
D01OBV
Former ID
DNC000896
Drug Name
Luteolin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468268]
Structure
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2D MOL

3D MOL

Formula
C15H10O6
InChI
InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
InChIKey
IQPNAANSBPBGFQ-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:15864
Target and Pathway
Target(s) DNA topoisomerase I Target Info Inhibitor [535459]
Lyso-PAF: acetyl-CoA acetyltransferase Target Info Inhibitor [538004]
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 468268(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5215).
Ref 535459Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J. 2002 Sep 1;366(Pt 2):653-61.
Ref 538004Inhibition of lysoPAF acetyltransferase activity by flavonoids. Inflamm Res. 1996 Nov;45(11):546-9.

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